Modular Assembly of Cell Systems Biology Models Using P systems

TitleModular Assembly of Cell Systems Biology Models Using P systems
Publication TypeJournal Papers
Year of Publication2009
AuthorsRomero-Campero, F. J., Twycross J., Cámara M., Bennett M., Gheorghe M., & Krasnogor N.
Journal TitleInternational Journal of Foundations of Computer Science
PublisherWorld Scientific
Place PublishedLondon, U.K.
Date Published01/2009

In this paper we propose an extension of a systems/synthetic biology modelling
framework based on P systems that explicitly includes modularity. Modularisation in
cellular systems can be produced by chemical specificity, spatial localisation and/or temporal
modulation within cellular compartments. The first two of these modularisation
features, the focus of this paper, can be easily specified and analysed in P systems using
sets of rewriting rules to describe chemical specificity and membranes to represent spatial
localisation. Our methodology enables the assembly of cell systems biology models by
combining modules which represent functional subsystems. A case study consisting of a
bacterial colony system is presented to illustrate our approach.

KeywordsModular Biology, P systems, Synthetic Biology, Systems Biology
Impact Factor



81/92 - Q4

ISSN Number0129-0541